Molecular biologists from the Gladstone Institute in the United States have finally uncovered the mechanism of folding DNA into a compact superstructure structure, which long time was not clear. This will allow you to learn how different proteins regulate the activity of genes, allowing the cells to grow and perform their functions.
When the chromosomes are collapsed, the formation of topologically associated domains of DNA, in which genes interact with each other much more actively than other areas.
Scientists have determined that one of the main roles in the process of twisting the protein CTCF plays. Its function was able to determine by removing a protein from cells of experimental animals. In the result of genes within the same plot were more likely to communicate with other domains.
According to the researchers, the findings will help determine the causes of certain diseases, including cancer and birth defects.
IReactor earlier reported that scientists have called the most «evil» social network of the Internet.